After patients had lost an average of 19.3 pounds with Xenical (orlistat) plus a reduced-calorie diet, half of them continued taking Xenical (120 mg of orlistat) three times per day plus a weight maintenance diet for another year, while the other half of patients were given Alli (60 mg of orlistat) instead. Weight loss at the end of the second year was 12.3 pounds for those who kept taking Xenical (120 mg of orlistat) versus 9.9 pounds for those given Alli (60 mg of orlistat) compared to 6.9 pounds for those who were switched from Xenical to a placebo.
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