Meal replacement shakes caused a dramatic difference in weight loss or weight gain over a 5-year period according to a 2000 paper.
Weight difference in men: -12.8 lbs vs +14.7 lbs, a difference of 27.5 lbs The average weight loss in 50 men who used meal replacement shakes was 12.8 pounds after five years versus a weight gain of 14.7 pounds for a group of “142 matched male controls”. This is a difference of 27.5 pounds for men.
Weight difference in men: -9.2 lbs vs +14.3 lbs, a difference of 23.5 lbs The average weight loss in 84 women who used meal replacement shakes was 9.2 pounds after five years versus a weight gain of 14.3 pounds for a group of “247 female controls”. This is a difference of 23.5 pounds for women.
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