Morbidly obese patients given the lowest dose of Qnexa, containing 3.75 mg of phentermine plus 23 mg of Topamax (topiramate), lost an average weight loss of 18 pounds versus 6 pounds with placebo after one year, or 5.1 percent of body weight versus 1.6 percent with placebo according to a press release from press release from Vivus, Inc, the company developing the drug.
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