“The digestion, absorption, and metabolism of fructose differ from those of glucose,” notes a paper by obesity researcher George Bray and others. [LIver] metabolism of fructose favors de novo lipogenesis [that is, the conversion of carbohydrates to fat]. “In addition, unlike glucose, fructose does not stimulate insulin secretion or enhance leptin production,” they note. “Because insulin and leptin act as key afferent signals in the regulation of food intake and body weight, this suggests that dietary fructose may contribute to increased energy intake and weight gain.” Comment: A recent study also found that fructose increases appetite, whereas glucose decreases appetite. This is because fructose metabolism requires an enzyme that depletes ATP, the universal energy molecule, whereas, glucose increases ATP.
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