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  • Zonegran (zonisamide) 400 mg per day causes weight loss of 16.1 lbs in 1 year vs 8.8 lbs w/ placebo

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, October 15, 2012 1:57 pm Email this article

    Zonegran (zonisamide), an anti-seizure drug, given at a dose of 400 mg per day, in addition to diet and lifestyle counseling by a dietitian, caused a weight loss of 16.1 lbs in one year vs 8.8 lbs with placebo according to a new study by Kishore M. Gadde, MD from Duke University Medical Center in Durham, North Carolina, USA, David B. Allison, PhD, George A. Bray, MD and others.


    Subjects: 225 obese adults

    The study involved 225 obese people with an average body mass index (BMI) of 37.6.

    The participants included 134 women and 91 men without diabetes mellitus.

    The study was conducted from January 9, 2006, through September 20, 2011, at Duke University Medical Center in Durham, North Carolina, USA.


    Gadde KM, Kopping MF, Wagner HR, Yonish GM, Allison DB, and Bray GA. Zonisamide for Weight Reduction in Obese Adults: A 1-Year Randomized Controlled Trial. Arch Intern Med 2012; published early on-line.

    Author’s Correspondence

    Kishore M. Gadde, MD
    Obesity Clinical Trials Programme
    Box 3292
    Duke University Medical Center
    Durham, NC 27710, USA
    919-668-0208 phone
    .(JavaScript must be enabled to view this email address)

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