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  • Intensive glucose-lowering treatment resulted in 4% HIGHER risk of death according to meta-analysis


    Posted by .(JavaScript must be enabled to view this email address)
    Friday, October 14, 2011 10:25 am Email this article
    Intensive glucose-lowering treatment does NOT lower the risk of death in Type 2 diabetics according to a meta-analysis of 13 studies.

    The total risk of death was 4% HIGHER in those given intensive glucose-lowering treatment compared to those who were not given these treatments, however, the difference was not statistically significant, meaning this difference may be due to random chance. Cardiovascular Deaths

    Cardiovascular Deaths 11% GREATER in the Intensive glucose-lowering treatment group

    Intensive glucose-lowering treatment does NOT lower the risk of death from cardiovascular disease either.

    The analysis found cardiovascular deaths were 11% GREATER in those given Intensive glucose-lowering treatment than those not, however, the difference was not statistically significant, meaning the difference might be due to random chance.

    “Intensive treatment did not significantly affect all cause mortality (risk ratio 1.04, 99% confidence interval 0.91 to 1.19) or cardiovascular death (1.11, 0.86 to 1.43),” the wrote.

     

    Subjects

    Subjects: 13 studies,34,533 patients, 18,315 received intensive glucose lowering treatment, 16,218 standard treatment

    The analysis looked at 13 studies, with a total of “34,533 patients, 18,315 received intensive glucose lowering treatment and 16,218 standard treatment.”

    REFERENCE

    Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright J, Gueyffier F, Cornu C. Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials. BMJ. 2011, 343:d4169.

    The full text of the article is posted here:
    http://www.bmj.com/content/343/bmj.d4169.full

    AUTHOR’S CONTACT INFORMATION

    Catherine Cornu
    Centre d’Investigation Clinique
    Hôpital Louis Pradel, 48
    Avenue du Doyen Lépine
    69500-Bron, France
    .(JavaScript must be enabled to view this email address)

     

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