Topamax (topiramate) caused average weight gain of 5.3 lbs in six months in migraine suffers

Posted by .(JavaScript must be enabled to view this email address)
Monday, April 04, 2011 3:26 pm Email this article
Topamax (topiramate) caused average weight loss of 5.3 lbs in six months in patients given the drug for as a preventative against migraine headaches according to a recent study. Subjects

Subjects: 331 adults, mostly women, with 3-12 migraines per month

The study involved 331 subjects (172 topiramate, 159 amitriptyline) who had 3 to 12 migraines per month.

Eighty-five percent 85% female, and 85% were white.

The average age was 39-years-old.

Their average starting weight was 169 lbs.

 

Dose

Dose: 25 mg per day increased to 100 mg per day

The dose used was 25 mg per day of either topiramate (Topamax) or amitriptyline (Elavil), “subsequently titrated to a maximum of 100 mg/d (or the maximum tolerated dose).”

REFERENCE

Dodick D, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg S, Hulihan J. Topiramate versus amitriptyline in migraine prevention: A 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. Clin Ther. 2009 Mar, 31(3):542-59.

AUTHOR’S CONTACT INFORMATION

David W. Dodick, MD
Department of Neurology
Mayo Clinic Hospital
5777 E. Mayo Boulevard
Phoenix, AZ 85054 USA
.(JavaScript must be enabled to view this email address)

Articles on the same subject can be found here:

• Topamax (topiramate)