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  • Topamax (topiramate) caused average weight gain of 5.3 lbs in six months in migraine suffers

    Posted by .(JavaScript must be enabled to view this email address)
    Monday, April 04, 2011 3:26 pm Email this article
    Topamax (topiramate) caused average weight loss of 5.3 lbs in six months in patients given the drug for as a preventative against migraine headaches according to a recent study. Subjects

    Subjects: 331 adults, mostly women, with 3-12 migraines per month

    The study involved 331 subjects (172 topiramate, 159 amitriptyline) who had 3 to 12 migraines per month.

    Eighty-five percent 85% female, and 85% were white.

    The average age was 39-years-old.

    Their average starting weight was 169 lbs.



    Dose: 25 mg per day increased to 100 mg per day

    The dose used was 25 mg per day of either topiramate (Topamax) or amitriptyline (Elavil), “subsequently titrated to a maximum of 100 mg/d (or the maximum tolerated dose).”


    Dodick D, Freitag F, Banks J, Saper J, Xiang J, Rupnow M, Biondi D, Greenberg S, Hulihan J. Topiramate versus amitriptyline in migraine prevention: A 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group noninferiority trial in adult migraineurs. Clin Ther. 2009 Mar, 31(3):542-59.


    David W. Dodick, MD
    Department of Neurology
    Mayo Clinic Hospital
    5777 E. Mayo Boulevard
    Phoenix, AZ 85054 USA
    .(JavaScript must be enabled to view this email address)

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