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  • Empatic (120 mg Zonegran SR plus 360 mg Wellbutrin SR) caused weight loss of 12.1% in 11 months

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    Tuesday, October 14, 2008 7:38 am Email this article
    People given Empatic, a combination of 120 mg of sustained-release Zonegran (zonisamide) plus 360 mg of sustained-release Wellbutrin SR (bupropion), lost an average of 12.1 percent of body weight after eleven months according to a press release from Orexigen Therapeutics, the company developing the drug. Subjects

    Subjects: 45 of 85 completed the study

    Of the 85 people who started the study with this particular dose of the drugs, 45 completed it (53 percent).


    10% Weight Loss

    Two-thirds of patients lost at least 10%

    Half of patients who completed the study (25 of 47) lost at least 10 percent of their body weight.


    Landbloom R. Long term weight loss from a dose optimization study with zonisamide sr and bupropion sr. Presented at: The obesity society annual scientific meeting; oct. 5, 2008; phoenix. abstract 61-OR, according to Company Press Release “Orexigen(R) Therapeutics Reviews Significant Data Regarding Its Obesity Product Candidates : Empatic™ Shows Long-Term Weight Loss, Improved Quality of Life; Contrave(R) Reduces Rate of Metabolic Syndrome by Half”:http://ir.orexigen.com/releasedetail.cfm?ReleaseID=338736


    Articles on the same subject can be found here:


    On Dec 15, 2008 at 7:26 pm tara wrote:

    . . . . .

    I lost 40 lbs on topamax which got me to 130lbs. However, the cognitive side effects were awful. I know zonegran is supposed to have less cognitive side effects and I have thought of trying it. However I really need all the memory and thinking skills I have now.

    On Dec 15, 2008 at 11:08 pm Larry Hobbs wrote:

    . . . . .


    Thanks for your input.

    You might want to read this article about how Dr. Jay Piatek uses Zonegran in his patients.

    He usually combines it with phentermine.

    He starts with a low dose an increases the dose VERY slowly to reduce side effects.


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