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Empatic (120 mg Zonegran SR plus 360 mg Wellbutrin SR) caused weight loss of 12.1% in 11 months
Tuesday, October 14, 2008 7:38 am Email this article
People given Empatic, a combination of 120 mg of sustained-release Zonegran (zonisamide) plus 360 mg of sustained-release Wellbutrin SR (bupropion), lost an average of 12.1 percent of body weight after eleven months according to a press release from Orexigen Therapeutics, the company developing the drug. Subjects
Subjects: 45 of 85 completed the study
Of the 85 people who started the study with this particular dose of the drugs, 45 completed it (53 percent).
10% Weight Loss
Two-thirds of patients lost at least 10%
Half of patients who completed the study (25 of 47) lost at least 10 percent of their body weight.
Landbloom R. Long term weight loss from a dose optimization study with zonisamide sr and bupropion sr. Presented at: The obesity society annual scientific meeting; oct. 5, 2008; phoenix. abstract 61-OR, according to Company Press Release “Orexigen(R) Therapeutics Reviews Significant Data Regarding Its Obesity Product Candidates : Empatic™ Shows Long-Term Weight Loss, Improved Quality of Life; Contrave(R) Reduces Rate of Metabolic Syndrome by Half”:http://ir.orexigen.com/releasedetail.cfm?ReleaseID=338736
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On Dec 15, 2008 at 7:26 pm tara wrote:
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I lost 40 lbs on topamax which got me to 130lbs. However, the cognitive side effects were awful. I know zonegran is supposed to have less cognitive side effects and I have thought of trying it. However I really need all the memory and thinking skills I have now.
On Dec 15, 2008 at 11:08 pm Larry Hobbs wrote:
. . . . .
Thanks for your input.
You might want to read this article about how Dr. Jay Piatek uses Zonegran in his patients.
He usually combines it with phentermine.
He starts with a low dose an increases the dose VERY slowly to reduce side effects.
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