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Type 2 Diabetics given Topamax lost 13.2 lbs vs 5.5 lbs for those given a placebo
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Monday, March 24, 2008 8:57 am Email this article
Type 2 diabetics given Topamax CR (topiramate controlled-release) lost an average of 13.2 pounds after four months versus 5.5 pounds for those given a placebo according to a study from researchers at the Dallas Diabetes and Endocrine Center in Dallas, Texas, USA. Weight Loss
Weight loss : 5.8% vs 2.3%
This weight loss was 5.8 percent of body weight versus 2.3 percent.
This means that those taking Topamax (topiramate) lost 3.5 percent more or 7.7 pounds more than those given a placebo.
Dose
Dose : Dose increased slowly over 7 weeks to 175 mg per day
The dose of Topamax CR (topiramate controlled-release) was increased slowly over 7 weeks to 175 mg per day for most subjects.
The final dose was 175 mg for 34 patients, 150 mg for one patient, 75 mg for one patient, and 50 mg for one patient.
Once the maximum dose was reached, the study continued for another 9 weeks so that the study lasted a total of 4 months (16 weeks).
Subjects
Subjects : 111 people
The study involved 111 people.
Completers
Completers : 72% given Topamax vs 81% given placebo
Seventy-two percent of those given Topamax completed the study compared to 81 percent of those given the placebo.
REFERENCE
Rosenstock J, Hollander P, Gadde K, Sun X, Strauss R, Leung A. A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients. Diabetes Care. 2007 Jun, 30(6):1480-86.
AUTHOR’S CONTACT INFORMATION
Julio Rosenstock, MD
Dallas Diabetes and Endocrine Center at Medical City
7777 Forest Lane, C-685
Dallas, TX 75230 USA
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