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  • Qnexa: Phentermine-Topriamate drug combo causes half of patients to lose an average of 25 pounds

    Posted by .(JavaScript must be enabled to view this email address)
    Friday, May 12, 2006 7:33 am Email this article
    A drug called Qnexa, which is really just a combination of phentermine and Topamax (topiramate), caused half of the patients to lose an average of 25.1 pounds after six months compared to 4.8 pounds for those given a placebo. Weight Loss

    Still losing after 6 months

    The patients taking the drug combination appeared to still be losing weight at the end of the study.

    Comment: Maximum weight loss with diet or drugs under strict condition usually occurs at about six months and patients tend to start regaining weight after that.

    The press release notes that patients given Qnexa lost more weight than with phentermine or Topmax alone, but they did not say how much patients lost with phentermine or Topmax alone.



    Subjects: 200 people

    The study involved 200 people—41 men and 159 women—who on average were 40-years-old and had a body mass index (BMI) of 38.

    Groups: Qnexa, phentermine, Topamax or placebo

    Subjects were given either Qnexa or phentermine alone or Topamax (topiramate) alone or a placebo.

    It appears that there were 50 people in each group.

    Dropouts: 4 patients on Qnexa versus 19 on placebo

    Ninety-two percent (92 percent) of patients given Qnexa completed the study compared to 62 percent of those given the placebo.



    Diet: Minus 500 calories per day

    Patients were asked to reduce calorie intake by 500 calories per day which should cause a weight loss of about one pound per week.

    Qnexa not yet approved by the FDA, but the ingredients are

    Qnexa, which is being developed by Vivus, is not yet approved by the U.S. Food and Drug Administration (FDA), however, your doctor can prescribe phentermine and Topamax (topiramate), the drug combination found in Qnexa.



    Comments: I don’t know the doses of phentermine or Topamax that are found in Qnexa

    The press release does not say how much phentermine or Topamax (topiramate) that Qnexa contains.



    Comments: I recommend you read about using Zonegran instead of Topamax

    For those interested in Topamax, I would also recommend reading about Zonegran which Dr. Jay Piatek has said is the new and improved Topamax that causes weight loss like Topamax, but without the side effects.

    Comments: Thank you to Dr. Charles Leroy for sending me this information

    Thank you to Dr. Charles Leroy for sending me this information.


    Press release from Vivus. VIVUS Announces Positive Phase 2 Clinical Trial Results With Qnexa, a Novel Therapy to Treat Obesity
    Over 50% of Obese Patients Experienced 10% or More Total Body Weight Loss in a 24-Week Study.


    Articles on the same subject can be found here:


    On Jun 13, 2008 at 6:05 pm Ray wrote:

    . . . . .

    I am in the current study and have lost 44 pounds in 3 months. It is a double blind study so I may be in the placebo group. Kinda doubt it. I have had no side effect that I have noticed and feel pretty good. My goal it to lose 100 in 1 year. I think I can make it.
    I am 43 years old starting weight was 307..
    My calorie intake is 1800 a day.
    I start riding a bike 5 miles twice a week about 3 weeks into the study. Didn't want to change everything at once..it looks real promising. It gave me the jump start and motivation to continue..

    On Jun 13, 2008 at 6:30 pm Larry Hobbs wrote:

    . . . . .


    Thank you very much for sharing your story.

    Congratulations on your weight loss.

    I posted your story here so that more people would see it.


    On Jul 02, 2008 at 12:48 pm Ray wrote:

    . . . . .


    Still going great! I am working at it and watching what I eat. Riding about 4 days a week now during my lunch break. I am -50 pounds now and half way to my 100 pounds. I do believe the next 50lbs are going to take 8 months to come off. I am not putting up the big numbers like before but for to see anything in the right direction is progress!

    On Jul 02, 2008 at 2:20 pm Larry Hobbs wrote:

    . . . . .



    I posted your update here so that more people will see it.


    On Nov 18, 2009 at 9:07 pm mike stamper wrote:

    . . . . .

    I was wondering if there has been any studies involving obese pulminary arterial hypertention patients.I was diagnosed with PAH in august of 2006 after an attempt at a liver transplant.Before surgery could take place I was put on Flolan-an infusion mixed medicine that was fed directly into my right arterial passage at my heart.It was inserted by the crushandt(sp?)method.My interior blood pressure reading was(by using a cathater reading)was67.I was put back on the transplant list until the Flolan was working well enough to attempt another transplant.I received a full-liver transplant on October 19th,2007.My internal reading had dropped to 37.All normal humans internal reading should be universally at 25.At the time of the first attempted transplant,my weight was 268lbs. By the time of the successfull transplant I was at 182lbs.I know the weight loss can be attributted to all the diuretics I was on to keep the dead liver inside me funtioning.After transplant the Pulminary team headed by Dr.Hector Cajigas at Detroit'sHenry Ford Health Systems determined that my internal pressure was not sufficent enough to remove the Flolan and infusion pump.A decision was made in early January to wheen me off the Flolan by decreasing the dodage slowly and replacing it with a one a day pill called Letairis.That took place in early Febuary 2009.Since then I have soared up to 255lbs!Am I a candidate for a test on this product called Qnexa?

    On Nov 18, 2009 at 9:47 pm Admin2 wrote:

    . . . . .


    Some diet drugs have been associated with pulmonary hypertension.

    Because of this, my guess is that drug companies would be scared away from including anyone with pulmonary hypertension in a study of diet drugs.

    I would suggest calling several University Obesity Centers and ask them if they have treated patients like you.

    I would try calling Universities such as:

    - Harvard
    - Yale
    - Columbia
    - UCLA
    - Stanford

    And any other big name University that you can think of.

    You can simply go on their website, such as http://www.Harvard.edu look ,for the main contact number for the University, and call and ask them for the phone number for their obesity treatment center.

    For example, with Harvard, the phone number, which is listed under "ABOUT HARVARD" >> "Contacts", it shows the phone number is:


    On Nov 19, 2009 at 2:55 pm Mike Stamper wrote:

    . . . . .

    Mr.Hobbs,thank you for the quick response.My gut instincts(no pun intended) told me about the same.Thanks for your consideration and time,Mike Stamper.

    On Nov 20, 2009 at 1:56 pm Admin2 wrote:

    . . . . .


    You're welcome.

    On Jun 27, 2010 at 12:09 am Bart Bush wrote:

    . . . . .

    I started on Topamax 3 days ago at 25mg each day for a week. I go up each week 25 mg till I reach 100mg. I am just wondering how long I have before it changes the taste of carbonated drinks?

    On Jun 27, 2010 at 7:36 am Larry Hobbs wrote:

    . . . . .


    I don't know that it changes the taste of carbonated drinks.

    On Jul 19, 2010 at 2:34 am Stacy Masiero wrote:

    . . . . .

    Yes, it does change the taste of carbonated drinks.

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