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  • Chart comparing weight gain from antipsychotic drugs

    Posted by .(JavaScript must be enabled to view this email address)
    Saturday, July 09, 2005 12:45 pm Email this article
    Below is a chart comparing weight gain during the first two-and-a-half months from various antipsychotic drugs.

    The chart below was redrawn from the paper referenced below (Newcomer, 2005).

    Abilify less weight gain than Zyprexa (1.5 lbs vs 9.2 lbs)

    Note that Abilify (aripiprazole) causes much less weight gain (1.5 pounds) after two-and-a-half months than Zyprexa (olanzapine) (9.2 pounds).

    Abilify, first-line antipsychotic, comparable to Zyprexa in efficacy for a fair amount of patients, with less weight gain

    I asked a psychiatrist who also specializes in weight loss if Abilify (aripiprazole) works as well as Zyprexa (olanzapine), and causes less weight gain.

    Here is what he said.

    “I believe Abilify is comparable to Zyprexa in its antipsychotic efficacy for at least a fair amount of patients. There’s definitely less weight gain, if any weight gain at all. I use it as a first-line antipsychotic.”


    Newcomer J. Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs. 2005, 19 Suppl 1:1-93.


    John W. Newcomer
    Department of Psychiatry
    Washington University School of Medicine
    St. Louis, Missouri 63110, USA
    .(JavaScript must be enabled to view this email address)

    Articles on the same subject can be found here:


    On Mar 14, 2008 at 9:53 am Nick wrote:

    . . . . .

    This is a very interesting chart. I gained 40 pounds on Zyprexa over 6 months and was so fed up with it that I requested a switch and was then prescribed Abilify. I almost threw up during the middle of the 1st night of taking the medicine, but am willing to go through the initial side effects to see if it improves my hypersomnia and weight gain.

    On Mar 14, 2008 at 11:04 am Larry Hobbs wrote:

    . . . . .


    Thanks for sharing your story.

    Sorry to hear about your weight gain from Zyprexa.

    A psychiatrist who also helps patients lose weight told me that Zyprexa is a miracle drug for certain conditions, but as the chart shows, Zyprexa is about as bad as it gets when it comes to causing weight gain.

    Please feel free to share your comments about this article.




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