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  • Zonegran (zonisamide) helps bipolar disease and causes weight loss of 19.8 lbs after one year

    Posted by .(JavaScript must be enabled to view this email address)
    Tuesday, June 28, 2005 4:41 am Email this article
    Zonegran (zonisamide) improves depression and mania in people with bipolar disease (manic-depression) and causes an average weight loss of 19.8 pounds after one year according to a new study. Average weight loss

    The average weight loss was:

    Note: This is not unusual for 80 percent or more of patients to drop out of studies that last for a year such as in diet drug studies.

    80% showed improvement in symptoms

    Eighty percent of patients showed moderate improvement in their bipolar symptoms, while one-third (33%) showed marked improvement.

    One-third showed worsening of symptoms

    One-third of patients (32 percent) stopped the drug because of a worsening of mood.

    Average dose was 249 mg per day

    Zonegran (zonisamide) was started at a dose of 100 mg per day and increased 100 mg per day every week, as necessary, to a maximum dose of 800 mg per day.

    The average dose Zonegran (zonisamide) was 249 mg per day, only about half as much as given in the study to treat binge eating (563 mg per day).

    8% dropped out due to side effects

    Only 8 percent of patients—5 of 55—dropped out of the study due to side effects.

    This is a much lower percentage of dropouts than in the study which tested Zonegran (zonisamide) for binge eating disorder where nearly half the patients—7 of 15—dropped out due to side effects.

    I assume this is because the average dose was only about half as much in this study (249 mg per day versus 563 mg per day).


    McElroy SL, Suppes T, Keck PJ, Black D, Frye M, Altshuler L, Nolen W, Kupka R, Leverich G, Walden J, Grunze H, Post R. Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial. J Clin Psychiatry. 2005 May, 66(5):617-24.


    Susan L. McElroy, M.D.
    Division of Clinical Neuroscience
    Department of Psychiatry
    University of Cincinnati College of Medicine
    P.O. Box 670559
    231 Albert Sabin Way
    Cincinnati, OH 45267-0559, USA
    .(JavaScript must be enabled to view this email address)).

    Articles on the same subject can be found here:


    On Sep 27, 2006 at 6:33 am Trisha Owens wrote:

    . . . . .

    I have been taking zonegran for 2 months now at a dose of 400 mg for epilepsy. I have noticed a definate decrease in weight. When I started the medication I weighed 194 lbs. and I am 5' 7". Two months later I have dropped down to 182 lbs. Thats 12 lbs in two months. So I am experiencing a very rapid weight loss with zonegran and am very happy with it.

    All my cravings are still there and I am still hungry as usual, but with a remarkable difference. I can only eat like maybe a fourth of whats in front of me. Sometimes I can eat more, but I get so full so quickly. Almost like I had my stomach stapled! I agree with not craving the carbonated soda. Now ice water tastes wonderful.

    On Sep 27, 2006 at 9:15 am Larry Hobbs wrote:

    . . . . .


    Very interesting. Thank you for sharing your story.

    On Aug 13, 2011 at 12:57 am Rp wrote:

    . . . . .

    The problems I have is that I cant go to sleep or stay asleep when taking it.

    On Aug 13, 2011 at 9:13 am Admin2 wrote:

    . . . . .


    Thank you for sharing your story.

    Lack of sleep causes weight gain, so I would avoid anything that interferes with sleep.

    Larry Hobbs

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